The 2021 North Dakota State Bison football team represented the North Dakota State University in the 2021 NCAA Division I FCS football season.

The Bison competed as members of the Missouri Valley Football Conference and were led by third-year head coach Matt Entz.

They played their home games at Fargodome in Fargo, North Dakota.

The Bison finished their regular season with a 10–1 record (7–1 in conference), losing only to South Dakota State.

[1] They were seeded second in the FCS postseason tournament and received a first-round bye; they then defeated Southern Illinois, East Tennessee State, and James Madison to reach the championship game.