The Sooners were led by Patty Gasso in her twenty-seventh season, and played their home games at OU Softball Complex.

They advanced to the 2021 Women's College World Series, where they defeated Florida State in three games to win their fifth championship in program history.

[2] The Sooners homered in 58 of their 60 games, including 45 multi-home run games, and set the NCAA Division I single-season record for team batting average (.405), team slugging percentage (.778), on-base percentage (.490), home runs (161), runs scored (638), runs per game (10.63), home runs per game (2.68) and total bases (1,279).

[3] They also set Women's College World Series records for home runs (15), runs scored (49) and hits (67).

[4] Pitchers Catchers Outfielders Infielders Utility