The 2021 Oklahoma State Cowboys baseball team represented Oklahoma State University during the 2021 NCAA Division I baseball season.

The Cowboys played their home games at O'Brate Stadium as a member of the Big 12 Conference.

They were led by head coach Josh Holliday, in his 9th season at Oklahoma State.

This was the program's first season at O'Brate Stadium, after the 2020 season was canceled prior to the opening game at the ballpark due to the COVID-19 pandemic.

The 2020 Oklahoma State Cowboys baseball team notched a 13–5 record in February and early March; however, the remainder of the season was abruptly halted on March 13, 2020, when the Big 12 Conference canceled the remainder of the athletics season due to the Coronavirus pandemic.