The 2021 Ole Miss Rebels football team represented the University of Mississippi in the 2021 NCAA Division I FBS football season.

The Rebels played their home games at Vaught–Hemingway Stadium in Oxford, Mississippi, and competed in the Western Division of the Southeastern Conference (SEC).

They were led by second-year head coach Lane Kiffin.

[1] In the preseason media poll, Ole Miss was predicted to finish 4th in the West Division.

[2] at Mercedes-Benz Stadium • Atlanta, GA at Vaught–Hemingway Stadium • Oxford, MS at Vaught–Hemingway Stadium • Oxford, MS *Originally scheduled to kickoff at 7:00 p.m. CST but was delayed due to inclement weather.