The 2021 Samford Bulldogs football team represented Samford University in the 2021 NCAA Division I FCS football season as a member of the Southern Conference (SoCon).

The Bulldogs were led by seventh-year head coach Chris Hatcher and played their home games at Seibert Stadium in Homewood, Alabama.

[1] at Seibert Stadium, Homewood, Alabama Second quarter Third quarter Fourth quarter at Ben Hill Griffin Stadium, Gainesville, Florida

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