The 2021 Settimana Internazionale di Coppi e Bartali was a road cycling stage race that took place between 23 and 27 March 2021 in the Italian region of Emilia-Romagna and in San Marino.

It was the 36th edition of the Settimana Internazionale di Coppi e Bartali and was part of the 2021 UCI Europe Tour as a category 2.1 event.

[1][2] Nine UCI WorldTeams, seven UCI ProTeams, seven UCI Continental teams, and two national teams made up the twenty-five teams that participated in the race.

[3] All but three teams entered seven riders; Team Jumbo–Visma and Trek–Segafredo each entered six riders, while Deceuninck–Quick-Step entered only five, for a total of 171 riders.

[4][5] UCI WorldTeams UCI ProTeams UCI Continental Teams National Teams