[3] In a primary field of four candidates, St. Louis Treasurer Tishaura Jones and Alderwoman Cara Spencer advanced to the general election.

Krewson had faced criticism during her term for her perceived mishandling of Black Lives Matter protests in the summer of 2020, with numerous demonstrations outside the mayor's home and calls for her to resign.

[3] Some also speculated that Proposition D, a ballot measure passed by St. Louis voters with 68% of the vote in November 2020, would have made it more difficult for Krewson to survive a primary challenge.

[3] In a primary field of four candidates, St. Louis Treasurer Tishaura Jones and Alderwoman Cara Spencer advanced to the general election.

[4] The two women defeated President of the St. Louis Board of Aldermen Lewis E. Reed as well as utility manager Andrew Jones.