The venue for Game 1 was originally named as the Melbourne Cricket Ground, however, due to a COVID-19 outbreak in Melbourne during the lead up to the match, it was relocated to Queensland Country Bank Stadium in Townsville.

[1] Game 2 was played at Suncorp Stadium as scheduled.

[2] Game 3 was originally scheduled to be played at Stadium Australia in Sydney, however was moved, firstly, to McDonald Jones Stadium in Newcastle due to the deteriorating COVID-19 situation in Sydney,[3] before being relocated again, to Cbus Super Stadium in Gold Coast.

These relocations meant that the series was the first entirely staged in a single state and the first games held in both Townsville and on the Gold Coast.

1 - With the State of Origin series returning to the middle of the NRL season, Wayne Bennett would step back from his head coaching role with Queensland, Paul Green picking up the job for 2021.