The 15th edition of the Strade Bianche was held on 6 March 2021.

Starting and finishing in Siena, Tuscany, Italy, it was the third event of the 2021 UCI World Tour.

[1] Twenty-five teams participated in the race, including all nineteen UCI WorldTeams and six UCI ProTeams.

Of these riders, 118 finished, while a further 20 riders finished over the time limit.

[2][3] UCI WorldTeams UCI ProTeams This cycling race article related to Italian cycling is a stub.