The 2021 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2021 NCAA Division I FCS football season.

Led third-year head coach Clarence McKinney, the Tigers compiled an overall record of 2–8 with a mark of 2–6 in conference play, placing fifth in the SWAC's West Division.

Texas Southern played home games at BBVA Compass Stadium in Houston.

Texas Southern's game against North American on October 2 was considered an exhibition game.

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