The 2021 Alabama State Hornets football team represented Alabama State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during 2021 NCAA Division I FCS football season.

The Hornets were led by fourth-year head coach Donald Hill-Eley for the first seven games of the season before he was fired on November 1.

[1] The team's defensive coordinator, Travis Pearson, was named interim head coach for the remainder of the season.

Alabama State compiled an overall record of 5–6 with a mark of 3–4 in conference play, tying for fourth place in the SWAC East Division.

The team played home games at New ASU Stadium in Montgomery, Alabama.