The 2021 WGC-FedEx St. Jude Invitational was a professional golf tournament being held August 5–8 at TPC Southwind in Memphis, Tennessee.

[1] Abraham Ancer won the event after making a birdie at the second hole of a sudden-death playoff against Sam Burns and Hideki Matsuyama.

TPC Southwind was designed by Ron Prichard, in consultation with tour pros Hubert Green and Fuzzy Zoeller.

TPC Southwind opened in 1988, and is a member of the Tournament Players Club network operated by the PGA Tour.

Tournament winners, whose victories are considered official, of tournaments from the Federation Tours since the prior season's WGC Invitational with an Official World Golf Ranking Strength of Field Rating of 115 points or more.