[4] His younger brother Alex played college golf at Wake Forest University in North Carolina.

Due to his results on the 2015 and 2016 seasons of the European Tour he obtained an automatic selection for the 2016 Ryder Cup.

In November 2016, Fitzpatrick won the DP World Tour Championship, Dubai by one shot over Tyrrell Hatton, for the third win of his career.

[18] In September 2021, Fitzpatrick played on the European team in the 2021 Ryder Cup at Whistling Straits in Kohler, Wisconsin.

The U.S. team won 19–9 and Fitzpatrick went 0–3–0 including a loss in his Sunday singles match against Daniel Berger.

Fitzpatrick won on the third playoff hole after hitting his approach shot to within one foot to set up the winning birdie.

[22] In September 2023, Fitzpatrick played on the European team in the 2023 Ryder Cup at Marco Simone Golf and Country Club in Guidonia, Rome, Italy.

The European team won 16.5–11.5 and Fitzpatrick went 1–2–0 including a loss in his Sunday singles match against Max Homa.

In October 2023, Fitzpatrick won the Alfred Dunhill Links Championship with a final round 66 on the Old Course at St. Andrews.

[23] Fitzpatrick appeared in the sports documentary series Full Swing, which premiered on Netflix on 15 February 2023.

[24] PGA Tour playoff record (1–0) *Note: The 2023 Alfred Dunhill Links Championship was shortened to 54 holes due to rain.