The Blue Bombers entered the season as the defending Grey Cup champions for the first time in 30 years, having ended the franchise's lengthy drought with last year's championship win in the 107th Grey Cup game.

The Blue Bombers qualified for the playoffs for the fifth consecutive season following a victory over the Edmonton Elks on October 16, 2021.

[4][5] On June 15, 2021, the league released the revised 14-game schedule with regular season play beginning on August 5, 2021.

[10][11] Due to the shortening of the season, the CFL confirmed that pre-season games would not be played in 2021.

[6] [12] The Blue Bombers initially had a schedule that featured 18 regular season games beginning on June 10 and ending on October 30.