It was held in Santo Domingo, Dominican Republic from September 11–20, 2021.

Dominican Republic won the gold medal (5th overall) after defeating the Mexico in the final by 3–0.

[1] A maximum of six (6) teams are qualified by the FIVB/NORCECA ranking, plus the points earned as results of the past 2019 XVIII Norceca Senior Women Pan- American Cup to participate in the 2021 Norceca XIX Senior Women Pan American Cup, Final Six.

Dominican Republic qualified as the host nation, and the remaining 5 qualifying teams are the top 5 in the NORCECA continental ranking as of January 1, 2021.

The following players received individual recognition following the conclusion of the tournament:[3]