The 2022–23 Creighton Bluejays women's basketball team represented Creighton University in the 2022–23 NCAA Division I women's basketball season.

The Bluejays, led by twenty-first year head coach Jim Flanery, played their home games at D. J. Sokol Arena and were members of the Big East Conference.

They lost in the quarterfinals of the Big East women's tournament to Seton Hall.

They received an at-large bid to the NCAA Women's Tournament as a 10th seed in Greensboro region where they defeated 7th seed Colorado in the first round, upset 2nd seed Iowa in the second round to advance to their first sweet sixteen appearance.

They upset 3rd seed Iowa State to advance to their first elite eight.