The 2022–23 EHF European League knockout stage began on 21 March with the Last 16 and ended on 28 May with the final at the Campushalle in Flensburg, Germany, to decide the winners of the 2022–23 EHF European League.
[1] In the Last 16, the 16 teams ranked 1st–4th in the group stage play against each other in two-legged home-and-away matches.
The eight winning teams advance to the quarterfinals, for another round of two-legged home-and-away matches.
The four quarterfinal winners qualify for the final four tournament at the Campushalle (formerly Flens-Arena) in Flensburg, Germany.
[2] The pairings for the last 16 and the quarterfinals are based on group stage standings, according to the following bracket.