The 2022–23 Women's EHF Champions League knockout stage began on 18 March with the playoffs and ended on 4 June 2023 with the final at the MVM Dome in Budapest, Hungary, to decide the winners of the 2022–23 Women's EHF Champions League.
In the playoffs, the eight teams ranked 2nd–6th in Groups A and B played against each other in two-legged home-and-away matches.
The four quarterfinal winners qualified for the final four tournament at the MVM Dome in Budapest, Hungary.
[1] The top six teams from Groups A and B qualified for the knockout stage.
The final four will be held at the MVM Dome in Budapest, Hungary on 3 and 4 June 2023.