The Seminoles played their home games at the Donald L. Tucker Center on the university's Tallahassee, Florida campus.

A contributing factor to their post season losses was the absence of Ta'Niya Latson who lead the team and the ACC in scoring during the regular season and won ACC Freshman of the Year.

As an eleven seed, the team played a First Four match against Missouri State, which they lost, 51–60, to end their season.

On March 21, 2022, Sue Semrau announced her retirement after 24 seasons as FSU head coach.

[3] She was succeeded by Seminoles associate head coach Brooke Wyckoff, who served as the interim head coach for the team during the 2020–21 season during Semrau's leave of absence.