The Cowgirls, led by second year head coach Lynn Kennedy, played their home games at The Legacy Center located on the McNeese State University campus in Lake Charles, Louisiana.

They qualified for the 2022 Southland Conference women's basketball tournament as the No.

Receiving 98 votes, the Cowgirls were picked to finish sixth in the conference.

[2] Kali Chamberlin was selected as a returning member of the Preseason All Conference first team.

Desirae Hansen was selected as a member of the second team for the third time.