The 2022–23 Southeastern Louisiana Lady Lions basketball team represented Southeastern Louisiana University in the 2022–23 NCAA Division I women's basketball season.

The Lady Lions were led by sixth-year head coach Ayla Guzzardo, and played their home games at University Center as members of the Southland Conference.

They defeated Texas A&M-Corpus Christi in the first round of the Southland women's tournament.

Their season ended when they were defeated by Incarnate Word in the finals.

[2] Hailey Giaratano was selected as a member of the second team for the third time.