The 2024–25 Southeastern Louisiana Lady Lions basketball team will represent Southeastern Louisiana University in the 2024–25 NCAA Division I women's basketball season.

The Lady Lions will be led by eighth-year head coach Ayla Guzzardo, and will play their home games at Pride Roofing University Center as members of the Southland Conference.

Their season ended when they were defeated by Texas A&M–Corpus Christi in the semi-finals.

[1] Junior forward Lexi Alexander was selected to the Preseason All-Conference first team.

Senior and junior guards Taylor Bell and Jalencia Pierre were selected to the second team.