The 2022–23 season is the 65th season in the club history of the handball branch of Zamalek SC, the season began with Egyptian Super Cup on the 10 September 2022, as Zamalek competes for the Egyptian Handball League, Egyptian Cup and African Handball Super Cup, Arab Handball Championship of Champions and African Handball Champions League, African Cup Winners' Cup.

Source: Competitions (Round 1)

(Round 2) (Round 1) (Round 2) (Round 3) (quarter-finals) (semi-finals) (finals)

(Round 1) (Round 2) (Round 3) (Round 4) (quarter-finals) (semi-finals) (finals) (Round 1) (Round 2) (Round 3) (Round 4) (Round 5) (Round 6) (Round 7) (Round 8) (Round 9) (Round 10) (Round 11) (Round 12) (Round 13) (Round 14) (Round 15) (Round 16) (Round 17) (Round 1) (Round 2) (Round 3) (Round 4) (Round 5) (Round 6) (Round 7) (Round 8) (Round 9) (Round 10) (Round 1) (Round 2) (Round 3) (Round 4) (Round 5) (Round of 32) (Round of 16) (quarter-finals) (semi-finals) (third place) (semi-finals) (finals) (Round 1) (Round 2) (Round 3) (Round 4) (quarter-finals) (semi-finals) (finals)