The Knights, led by first-year head coach Tobin Anderson, played their home games at the Rothman Center in Hackensack, New Jersey as members of the Northeast Conference.

In a unique circumstance, the semifinal between Saint Francis and Fairleigh Dickinson decided the NEC's automatic bid to the NCAA Tournament because Merrimack was in a transition period from Division II to Division I and ineligible for the NCAA Tournament.

1 seed by defeating Purdue, in the biggest upset in NCAA Tournament history in terms of point spread.

[1] The Knights lost in the Second Round to eventual Final Four participant Florida Atlantic.

[4] On April 25, 2022, the school announced that they were parting ways with head coach Greg Herenda after nine years at the position.