On March 17, 2023, during the first round of the 2023 NCAA Division I men's basketball tournament, the Purdue University Boilermakers played a college basketball game against the Fairleigh Dickinson University (Fairleigh Dickinson, also FDU) Knights at the Nationwide Arena in Columbus, Ohio.

1 seed in the NCAA Division I men's basketball tournament, and the second 16-seed overall after UMBC's win over Virginia in 2018.

[5] With Purdue set as a 23+1⁄2-point favorite heading into the game, Fairleigh Dickinson's victory was the biggest upset in terms of point spread in NCAA tournament history.

[8] A preseason Northeast Conference (NEC) coaches' poll picked the Knights to finish tied for sixth in their league.

[21] The game was televised nationally on TNT and announced by Andrew Catalon, Steve Lappas, and Jamie Erdahl.

[25] After halftime, Fairleigh Dickinson would outscore Purdue 7–5, before the first media timeout of the half, taking a three-point lead.

Fairleigh Dickinson, down by six points, went on their own 8–0 run to reclaim the lead, before a Zach Edey tip shot tied the game at 49–49.

On the next possession, Purdue would draw a foul, and Loyer made both free throws to make it a one score game.

After a missed opportunity, Purdue had a chance to tie the game, but instead Smith opted to try for a layup that was blocked by Moore.

However, Purdue would get another offensive opportunity to tie the game, but Loyer's three-point try was an airball and the Boilermakers were forced to foul with seven seconds left.

After two made free throws by Roberts, Fairleigh Dickinson would take a five-point lead and would go on to win 63–58.

In its immediate aftermath, the game was considered possibly the biggest upset in tournament history, mainly owing to Fairleigh Dickinson's significant underdog status; besides being the largest upset of all time by point spread, Fairleigh Dickinson had entered the tournament as the 68th and last-ranked team overall, and it had received the Northeast Conference's automatic bid despite losing the conference championship game (champion Merrimack was ineligible due to its transition from Division II).

The Owls' season ended with a 72–71 loss to San Diego State after the Aztecs' Lamont Butler hit a jump shot at the buzzer.

After Purdue's loss however, it was reported that there were no longer any perfect brackets remaining, only two days after the tournament started.

[35] In 2024, the Boilermakers again entered the NCAA Tournament as a #1 seed, showcasing a strong resurgence from the prior year's setback.

Despite their best efforts at redemption similar to that of Virginia, however, Purdue would ultimately lose in that year's championship game to the defending champions, the UConn Huskies, with a final score of 75–60.