The 2022 AFC Cup knockout stage was played from 9 August to 22 October 2022.
[1] A total of 12 teams competed in the knockout stage to decide the champions of the 2022 AFC Cup.
The extra time and penalty shoot-out were used to decide the winners if necessary (Regulations Article 9.3 and 10.1).
[1] The draw for the Zonal finals and the Inter-zone play-off semi-finals was held on 14 July 2022.
The Zonal finals were played over one leg, with the home team decided by draw.