The 2022 AFC Cup qualifying play-offs were played from 5 to 19 April 2022.
[1] A total of ten teams competed in the qualifying play-offs to decide three of the 39 places in the group stage of the 2022 AFC Cup.
Extra time and penalty shoot-out were used to decide the winner if necessary.
[1] The bracket of the qualifying play-offs for each zone was determined based on each team's association ranking, with the team from the higher-ranked association hosting the match.
The three winners of the play-off round advanced to the group stage to join the 36 direct entrants.