Melbourne won the premiership, defeating Brisbane by four points in the 2022 AFL Women's season 7 Grand Final.

In August 2021, Essendon, Hawthorn, Port Adelaide and Sydney – the four Australian Football League (AFL) clubs yet to receive an AFLW licence at the time – were granted licences to join the AFL Women's competition in what was then slated to be a 2022–23 season, meaning all 18 clubs would have an AFLW team for the first time.

[10] The round is held to acknowledge the significant contribution of Aboriginal and Torres Strait Islander women and girls to Australian football and the broader community.

[10] Aunty Pam Pederson, the youngest daughter of Sir Douglas Nicholls, was announced as the round's honouree, and all 18 teams wore specially-designed guernseys across the two weeks.

[17] Melbourne won its first AFL Women's premiership, defeating Brisbane by four points in the grand final, played at Brighton Homes Arena.

[15] All matches throughout season 7 were broadcast live on the Seven Network and Fox Footy, and could be streamed via Kayo, womens.afl and the official AFL and AFLW apps.