Cork entered the championship as defending champions in search of a third successive title, however, they were beaten by Tipperary in the Munster semi-final.

[1][2] The final was played on 22 May 2022 at Semple Stadium in Thurles, between Kilkenny and Limerick, in what was their first meeting in a final in five years.

[4][5] Kilkenny's Billy Drennan was the championship's top scorer with 1-40.

For the first time in its history, the Munster Under-20 Championship replaced its traditional straight knockout format with a group stage.

The All-Ireland semi-finals, which featured the defeated provincial finalists in 2018 and 2019, will be discontinued.