[1] For the fourth time in the last six seasons, the Astros won the ALCS to advance to the 2022 World Series, defeating the Yankees in a four-game sweep.

[9][10] This is the first postseason meeting between the two teams since the revelation of the Houston Astros sign stealing scandal, which included the 2017 American League Championship Series; however, despite allegations, there was no evidence of electronic sign-stealing during the 2019 season.

[17] The Astros responded in the bottom half of the inning when Martín Maldonado drove in Chas McCormick with an RBI double to tie the game at one.

After some early trouble, Verlander settled in, giving up only the one run and striking out eleven batters in six innings, passing Clayton Kershaw for the most postseason strikeouts in Major League history.

Yuli Gurriel grabbed the lead back for the Astros in the sixth with a lead-off homer, shortly followed by another home run by McCormick to bring the score to 3–1.

Anthony Rizzo hit a solo shot off of Rafael Montero in the eighth and the Yankees threatened with a single by Giancarlo Stanton and a two-out walk by Josh Donaldson to bring the go-ahead run to the plate.

Ryan Pressly was called on for the four-out save and struck out Matt Carpenter to end the eighth and finished off the game with a perfect ninth to give the Astros a 1–0 series lead.

The Yankees answered back the following inning, capitalizing on an Aaron Judge single and a throwing error by Valdez on a Giancarlo Stanton grounder that put runners at second and third.

In the eighth with a runner on, Judge hit what looked to be a go-ahead two-run homer off of reliever Bryan Abreu, but the wind blowing in from the open roof kept the ball in the park as Kyle Tucker caught it at the warning track.

Cristian Javier, who had pitched in a combined no-hitter at Yankee Stadium in June, made the first postseason start of his career for the Astros.

In the top of the second inning, Christian Vázquez hit a fly-ball to centerfield that ended up being dropped by Harrison Bader after a cross-up with Aaron Judge.

The error extended the inning and led to Chas McCormick hitting a two-run home run off Cole to give the Astros the early lead.

Yordan Alvarez then hit a line drive RBI single to right field to tie the game before Loáisiga was taken out for Clay Holmes.

In the series, pending free agent and MVP Aaron Judge went 1-for-12 with six strikeouts and two walks in the four game sweep, capping off a nightmarish end to a 62 home run season.