The 2022 Angelo State Rams football team represented Angelo State University as a member of the Lone Star Conference during the 2022 NCAA Division II football season.

Led by fifth-year head coach Jeff Girsch, the Rams compiled an overall record of 12–1 with a mark of 9–0 in conference play, winning the LSC title.

Angelo State received a first-round bye in the NCAA Division II Football Championship playoffs and beat Bemidji State in the second round before losing to Colorado Mines in the quarterfinals.

Angelo State played home games at the LeGrand Sports Complex in San Angelo, Texas.

[1] [2] at LeGrand Sports Complex, San Angelo, Texas Second quarter Third quarter Fourth quarter at Alumni Field, Golden, Colorado Second quarter Third quarter Fourth quarter Overtime at Astound Broadband Stadium, Midland, Texas Second quarter Third quarter Fourth quarter at LeGrand Sports Complex, San Angelo, Texas Second quarter Third quarter Fourth quarter at McArthur Field, Monmouth, Oregon Second quarter Third quarter Fourth quarter at LeGrand Sports Complex, San Angelo, Texas Second quarter Third quarter Fourth quarter at Altamirano Stadium, Silver City, New Mexico at LeGrand Sports Complex, San Angelo, Texas at Borderite Stadium, Blaine, Washington Second quarter Third quarter Fourth quarter at LeGrand Sports Complex, San Angelo, Texas at Memorial Stadium, Wichita Falls, Texas at LeGrand Sports Complex, San Angelo, Texas Second quarter Third quarter Fourth quarter at LeGrand Sports Complex, San Angelo, Texas Second quarter Third quarter Fourth quarter