Appalachian State played their home games at Kidd Brewer Stadium on the school's Boone, North Carolina, campus, and competed as a member of the East Division of the Sun Belt Conference.

On February 9, 2022, offensive coordinator Frank Ponce was hired as the quarterbacks coach for the Miami Hurricanes.

On 4th down, Trojan quarterback Gunnar Watson intentionally ran out of his own end zone for a safety.

On the kickoff, Ahmani Marshall returned the kick to the Mountaineers' 47-yard line with just 0:15 left to play.

On the final play of the game, Chase Brice threw a Hail Mary pass that Troy's defense tried to knock down, but Christian Horn caught the deflected pass and ran it in for the game-winning touchdown.