The Mountaineers compete in Division I of the National Collegiate Athletic Association (NCAA) and were a member of the Southern Conference (SoCon) between 1972 and 2014.

[4] Football home games are played at Kidd Brewer Stadium,[5] while basketball, volleyball, and indoor track and field events are held at the George M. Holmes Convocation Center.

[7] On May 26, 2020, Appalachian State announced that it would discontinue the men's soccer, indoor track and field, and tennis varsity teams effective immediately due to budget cuts resulting from the COVID-19 pandemic.

The head coach of the Appalachian State men's basketball team is currently Dustin Kerns, previously of the Presbyterian Blue Hose.

The Mountaineers achieved perhaps their biggest win in program history with a road upset of the fifth-ranked Michigan Wolverines, 34–32, on September 1, 2007.

They include Harold Alexander, Kerry Brown, Dexter Coakley, Dino Hackett, Larry Hand, Jason Hunter, Dexter Jackson, Corey Lynch, Rico Mack, Marques Murrell, Mark Royals, John Settle, Matt Stevens, Troy Albea, Daniel Wilcox, and Armanti Edwards.

[16] The Mountaineers wrestling team is coached by JohnMark Bentley and holds their home matches in Varsity Gymnasium.

Notable former Mountaineer wrestlers include former Olympians – Al Crawford (1948), Herb Singerman (1968), Ike Anderson (1988), and Dale Oliver (1988).

In 2017, Denzel Dejournette was named an All-American, the first wrestler to earn the honor since Kyle Blevins and Austin Trotman in 2012.

[17] During Appalachian's 43-year tenure in the Southern Conference, the Commissioner's and Germann Cups were awarded each year to the top men's and women's program in the league.

[19] [20] Audio and video of games and events can be accessed at the internet home of Appalachian State Mountaineers athletics.