[11][12] In October 2021, the Grand Prix was officially confirmed as the third of twenty-three races of the 2022 season at a FIA World Motor Sport Council meeting in Paris.

[3][14] Prior to the weekend, drivers were reminded by one of the two race directors, Eduardo Freitas, who was not appointed for this Grand Prix, that they are prohibited by the FIA's International Sporting Code from wearing jewellery when inside their cars, as it could cause safety issues, particularly if there is a fire when drivers are trying to extract themselves from their cars.

[8] Several other corners were reprofiled to encourage overtaking, most notably turn 13, which was widened to create additional racing lines.

Ricciardo ran wide at the start, crossing onto the grassy verge and hitting an unsighted culvert, which destroyed his front wing and the undertray of the car, forcing him to retire.

[16] Further changes, such as resurfacing the circuit with a tarmac compound designed to wear tyres out, were planned to take place after the 2021 edition, which was postponed from March to November,[16] before being cancelled and done later for the 2022 event.

The removal of the drag reduction system zone appeared to benefit those teams, such as Alpine and McLaren, who had minimised the aerodynamic porpoising of their cars.

Aston Martin's Sebastian Vettel, who was replaced by Nico Hülkenberg in the first two races due to coronavirus,[7] made his season debut.

[36] Williams's Alexander Albon carried a three-place grid penalty following a collision with Aston Martin's Lance Stroll at the previous round, the Saudi Arabian Grand Prix.

[38] Ferrari's Carlos Sainz Jr. set the fastest lap in the first session ahead of teammate Charles Leclerc and Red Bull's Sergio Pérez.

[39] Leclerc set the fastest lap in the second session ahead of Red Bull's Max Verstappen and Sainz.

[40] The third practice session took place at 13:00 local time on 9 April,[38] in which McLaren's Lando Norris set the fastest lap ahead of Leclerc and Pérez.

[42] Charles Leclerc set the fastest time for pole position ahead of Max Verstappen and Sergio Pérez.

[57] After a brief struggle with keeping the tyres warm at the restart, Leclerc maintained the lead ahead of Verstappen, while Pérez, who was overtaken by Lewis Hamilton at the start,[57] retook third position through DRS at turn 3 by lap 10.

[66] Alexander Albon was able to keep his hard compounds for 57 laps, before having to make his compulsory pit stop,[50] and finished 10th for Williams's first point of the season.