A member of the Ferrari Driver Academy since 2010, Stroll graduated to junior formulae in 2014, winning his first title at the Italian F4 Championship that year with Prema.

After two seasons at Williams, Stroll signed for Racing Point—having recently been acquired by his father—in 2019 to partner Sergio Pérez, finishing fourth at the rain-affected German Grand Prix.

Stroll has been teammates with Fernando Alonso since 2023, finishing a career-best tenth in the World Drivers' Championship that year.

He raced against future Formula One competitors Nicholas Latifi and Max Verstappen, and took two podium finishes as well as pole position at Homestead–Miami Speedway.

Despite missing the final round due to injury, Stroll emerged as series champion, taking seven race wins, thirteen podium finishes, and five pole positions.

[14] He competed against future Formula One competitors Antonio Giovinazzi, Charles Leclerc, George Russell and Alexander Albon, winning one race at the Hockenheimring and achieving six total podium finishes in the 33-race series.

He claimed the title with four races to go and ended the season a record 187 points clear of nearest competitor Maximilian Günther.

This was highlighted by George Russell, who stated at Le Castellet, where Stroll had inherited the lead from a slowing Nick Cassidy, who ended up finishing second, that "it's not a fair fight".

[20][14] Stroll crashed in practice for his debut race, the Australian Grand Prix, and received a grid penalty as this necessitated an unscheduled gearbox change.

At the Azerbaijan Grand Prix, Stroll had run in second place in the closing laps, but was passed by Valtteri Bottas just metres from the finish line.

Due to Red Bull drivers Daniel Ricciardo and Max Verstappen (respectively third and second) taking grid penalties, Stroll was promoted to second place on the starting grid, making him the youngest Formula One driver to start on the front row at the age of 18 years and 310 days.

Stroll's home race, the Canadian Grand Prix, ended on the first lap after a heavy collision with Brendon Hartley.

At the Chinese Grand Prix, Stroll criticized team strategy after finishing outside of the point-scoring positions for the second consecutive race.

[39] He was in second place when the race restarted after a red flag period before being passed by multiple cars including Pierre Gasly.

A string of retirements followed beginning with the Tuscan Grand Prix, where a mechanical failure caused him to crash heavily, having been running in fourth place.

[47] Shortly after the Bahrain Grand Prix was restarted following Romain Grosjean's accident, Stroll's car was flipped over after making contact with Daniil Kvyat at turn eight.

[48] At the Sakhir Grand Prix, he benefited from tire issues for the leading Mercedes cars to finish third, earning his third podium in Formula One.

A similar incident then happened to Max Verstappen later in the race, prompting tire manufacturer Pirelli to conduct an investigation into the failures.

[53] Stroll scored a point with tenth place at the French Grand Prix, having started nineteenth after being unable to set a representative lap time in qualifying.

He failed to set a qualifying time at the Australian Grand Prix due to a crash with Nicholas Latifi for which Stroll was penalised.

[55] He made three pit stops during the race and later received a penalty for weaving on the straight when defending against Valtteri Bottas, finishing twelfth.

A penalty for dangerous defending against teammate Vettel in the São Paulo Grand Prix sprint dropped Stroll to fifteenth on the grid for the race, in which he recovered to score a point in tenth place.

[63] Stroll missed all three days of pre-season testing at Bahrain International Circuit after suffering a cycling accident while training.

[76] He finished fourth at the Australian Grand Prix, his best result of the year, despite first-lap contact with Charles Leclerc and later running into the gravel at the second restart.

He finished outside the top ten at the Dutch and Italian Grands Prix; his practice running at Monza was curtailed by a fuel system failure and he then qualified in last place.

A heavy crash in qualifying at the Singapore Grand Prix caused his withdrawal from the weekend, with Aston Martin team principal Mike Krack stating that Stroll was "still feeling the after-effects" of the accident.

[78] After qualifying seventeenth at the Qatar Grand Prix, 1.1 seconds behind teammate Alonso's time, Stroll appeared to push his personal trainer in frustration as he exited the vehicle.

[81] Stroll started from the pit lane again at the Mexico City Grand Prix and retired with damage from a collision with Valtteri Bottas.

[citation needed] Stroll then qualified 13th for the Monaco Grand Prix but finished 14th after throwing his chance for points away when he got a puncture after hitting the wall in the middle of the race.

[87] Stroll bounced back with a seventh-place finish at his home race in Canada,[88] and achieved further points in Britain[89] and Hungary.