The 2022 Australian Open Men's Singles final was the championship tennis match of the men's singles tournament at the 2022 Australian Open, contested by sixth-seed Rafael Nadal and second-seed Daniil Medvedev.

It was a match of historic proportions for both players: Nadal was attempting to surpass an all-time joint record of 20 major men's singles titles, shared with his great rivals, Novak Djokovic and Roger Federer, by winning a record 21st major title; and to become the fourth man to complete the double career Grand Slam (after Roy Emerson, Rod Laver, and Djokovic).

In the second set, Nadal broke Medvedev's serve at 2–1 in a game featuring a 40 shot rally, and consolidated to take a 4–1 lead.

Nadal saved all three break points to hold and then broke Medvedev's serve at 4–4 with a backhand passing shot, a moment that was crucial to shifting the momentum of the match.

Nadal took a break lead in the fifth set at 2–2 with a running forehand down the line, and served for the championship at 5–4.

From 30–0 up in the game, Nadal committed two unforced errors and a double fault to allow Medvedev to break back.