Medvedev made his ATP Tour main draw debut at the 2015 Kremlin Cup, and in 2017, he participated in a singles major for the first time at Wimbledon.

In 2018, Medvedev won his first ATP Tour singles titles, and achieved a breakthrough in 2019, making his top 10 debut and reaching six consecutive tournament finals, including at the US Open.

[15][16][17] Medvedev studied physics and maths at a specialized school before graduating early and enrolling in economics and commerce at the Moscow State Institute of International Relations.

[25] In September 2019, he credited his marriage for the improvement of his tennis results: "Before I made a proposal, I had been on the 65th place in the ranking, and then in ten months I've won two major tournaments and entered the top 10.

[citation needed] Medvedev ended his junior career with an overall win–loss record of 109–43 and wins over several future stars including Alexander Zverev and Reilly Opelka.

[citation needed] As a qualifier, Medvedev made his ATP singles main draw debut at the 2016 Nice Open, losing to Guido Pella in three sets.

Three weeks later he earned his first singles ATP World Tour win at the 2016 Ricoh Open, defeating Horacio Zeballos in straight sets.

[citation needed] Medvedev was disqualified from the second round of the Savannah Challenger event (in Georgia, U.S.) for comments he made after the umpire ruled in favor of his opponent.

[30] Medvedev thought he had won a break point against his opponent Donald Young's serve, but chair umpire Sandy French ruled that his returning shot had gone out.

[citation needed] In June, he made it to the quarterfinals of the Rosmalen Grass Court Championships, defeating the 6th seed, Robin Haase, and Thanasi Kokkinakis before losing to Ivo Karlović in straight sets.

[citation needed] Medvedev registered his maiden Grand Slam match win at the 2017 Wimbledon Championships, defeating fifth seed and world No.

[36] Medvedev started the season strongly by reaching the final of the Brisbane International, defeating Andy Murray, Milos Raonic and Jo-Wilfried Tsonga en route, but then lost to Kei Nishikori.

He returned to form on the grass courts of Queen's Club, reaching his sixth semifinal of the season where he lost to Gilles Simon.

The North American hardcourt swing proved to be a momentous breakthrough in Medvedev's career, as he reached four tournament finals (in Washington, Montreal, Cincinnati, and the US Open), becoming only the third man in tennis history to do so (after Ivan Lendl and Andre Agassi).

He followed this up with a strong performance at the Rogers Cup, reaching his first Masters final after beating top 10 players Dominic Thiem and Karen Khachanov.

When the season resumed in August after a six-month hiatus due to the COVID-19 pandemic, Medvedev failed to defend his title at Cincinnati Masters, losing to Roberto Bautista Agut in the quarterfinals.

[63][64] At the ATP Finals, Medvedev won all his round-robin matches in straight sets, over Alexander Zverev, Novak Djokovic and Diego Schwartzman.

Medvedev recovered from a set- and break-deficit to defeat Rafael Nadal in the semifinals, before beating Dominic Thiem in the final, once again coming from a set down.

In singles, he defeated Kazakhstan's Alexander Bublik, India's Sumit Nagal, and Italy's Fabio Fognini to reach the quarterfinals.

[77] To start the North American hardcourt season, Medvedev competed at the Canadian Open, where he won the title after defeating Reilly Opelka in the final.

1 ranking the following fortnight if he reached the semifinals at the Miami Masters, but fell one match short, losing to defending champion Hubert Hurkacz in the quarterfinals.

[105] Medvedev started his North American summer hardcourt season by winning the title at the Los Cabos Open defeating Cameron Norrie in the final.

[112] Seeded 7th at the Australian Open, he defeated Marcos Giron and John Millman before losing to Sebastian Korda in straight sets in the third round.

The following week, Medvedev entered the Qatar ExxonMobil Open seeded third and won the tournament, defeating Andy Murray in straight sets in the final.

At the next Masters 1000 tournament in Indian Wells, Medvedev reached back-to-back quarterfinals after defeating 12th seed Alexander Zverev in the fourth round.

During the North American summer hardcourt swing, Medvedev reached the quarterfinals at the Canadian Open and the fourth round at the Cincinnati Masters, losing to Alex de Minaur and Alexander Zverev respectively.

[125] At the Rolex Shanghai Masters, he defeated Cristian Garín to record his 60th win of the year, becoming the second player of the season to accomplish this after Carlos Alcaraz.

He then won back-to-back 5-set matches against Hubert Hurkacz and Alexander Zverev, coming back from two sets down to defeat the latter, to reach his third Australian Open final.

[141] Initially possessing a short temper, Medvedev eventually learned to control himself and display a calm demeanor in important matches.

Medvedev suffers on clay due to his style of playing flat strokes and the fact that his movement, one of his biggest strengths on a hardcourt, is hampered.