The 2022 W Series Barcelona round was the second round of eight in the 2022 W Series, and took place at the Circuit de Barcelona-Catalunya in Spain on 21 May 2022.

[1] The event was an undercard to the 2022 Formula One World Championship round at the same circuit.

For the first of two events in 2022, the Tatuus–Toyota FT-60 chassis and engine combination would be used instead of the usual Tatuus–Alfa Romeo F3 T-318 car due to logistical hurdles related to the tight turnarounds between events.

[2] Jamie Chadwick led the drivers' championship on 50 points, 27 points ahead of Nerea Martí.

Jenner Racing led the teams' championship on 51 points, 10 points ahead of the Quantfury W Series Team.