It was held from March 2–6, 2022, with all tournament games played at the Bojangles Coliseum in Charlotte, North Carolina.
This was the first time since the 2016 edition that the tournament was held at a single neutral site location.
Winthrop lost in the finals to Longwood, ensuring the Lancers their first NCAA tournament appearance.
With the addition of North Carolina A&T before the season, the conference increased its membership to 12 teams and split into divisions for the first time since 2013–14.
The tiebreakers operate in the following order:[2] UNC Asheville got a higher seeding than Campbell due to the head-to-head record.