With their loss on September 17, the Cubs were officially eliminated from playoff contention for the second consecutive season.

[4] On March 11, 2022, the Cubs announced that manager David Ross had signed a three-year contract extension through the 2024 season with an option for 2025.

[7] On November 15, 2021, the Cubs announced they had parted ways with associate pitching, catching, and strategy coach Mike Borzello.

[10] As a result, the team owners voted unanimously to lockout the players stopping all free agency and trades.

[11][12] The Cubs officially signed three players, including free agent pitcher Marcus Stroman, prior to the lockout being put in place.