However, the delayed start to spring training meant that the regular season was postponed from its original March 31 Opening Day to April 7.

The National League adopted the designated hitter full-time, a draft lottery was implemented, the postseason expanded from ten teams to twelve, and advertising patches was allowed to appear on player uniforms and helmets for the first time.

Just before the White Sox were set to face off against the Kansas City Royals on August 30, it was announced by the team that manager Tony La Russa had to miss the game under the direction of his doctors, in order to get further medical testing.

[34] Prior to La Russa's departure from the White Sox, the team's record was an underachieving 63-65 and they were five games behind the Cleveland Guardians for first place in the American League Central.

The Guardians would officially clinch the American League Central on September 25, ending the White Sox's dreams of repeating as division champions.

Cease posted a 2–1 record in the month of June as a starter, with a 0.33 ERA in 27.1 innings pitched, 45 strikeouts, and an opponent batting average of .192.

[42] Anderson defeated Bichette in the final voting on July 8, becoming the first White Sox shortstop to earn a starting spot at the All-Star Game since Luis Aparicio in 1970.

[44] Dylan Cease finished second in the American League Cy Young Award voting, behind only Justin Verlander of the Houston Astros.