The Buffaloes played their home games on campus at Folsom Field in Boulder, Colorado.

This was one of the worst seasons in program history as Colorado lost all but three games by at least 25 points.

[2] After the season on December 3, Deion Sanders was hired as the head coach for 2023.

A Hall of Fame cornerback in the National Football League (NFL), he was previously the head coach for three years at Jackson State of the Southwestern Athletic Conference (SWAC).

[3][4] [5] Roster Last update: 11/6/22 at Folsom Field • Boulder, CO at Falcon Stadium • Air Force Academy, CO at Huntington Bank Stadium • Minneapolis, MN at Folsom Field • Boulder, CO at Arizona Stadium • Tucson, AZ at Folsom Field • Boulder, CO None Overtime at Reser Stadium • Corvallis, OR at Folsom Field • Boulder, CO at Folsom Field • Boulder, CO at Los Angeles Memorial Coliseum • Los Angeles, CA at Husky Stadium • Seattle, WA at Folsom Field • Boulder, CO