The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

[12] Gonzalez, Almonte, Fuentes, and Ruiz elected free agency, while Doyle was outrighted to the Albuquerque Isotopes.

On November 3, 2021, Trevor Story, Jon Gray, Jhoulys Chacín, and Chris Owings elected free agency.

[15] On December 15, 2022, the Rockies signed infielders Kyle Holder[16] and Tim Lopes[17] to minor league contracts.

The club signed pitchers Ty Blach[20] and J. D. Hammer[21] to minor league contracts on March 13, 2022, along with outfielder Scott Schebler.

[23] On March 16, 2022, the Rockies announced the signing of infielder José Iglesias and pitcher Chad Kuhl to 1-year major league contracts.

[27] When the lockout ended, the Rockies began spring training at Salt River Fields at Talking Stick on March 13, 2022.