A special election in District 36 was held on August 17, 2021, to fill the vacancy left by Democrat Alex Kasser, who resigned effective June 22, 2021.

Seven incumbent senators, Steve Cassano (D-4th), Kevin Witkos (R-8th), Mary Daugherty Abrams (D-13th), Paul Formica (R-20th), Will Haskell (D-26th), Craig Miner (R-30th), Dan Champagne (R-35th), did not attempt to run for reelection.

Democratic incumbent Saud Anwar was reelected to a third term after defeating Republican candidate Matt Harper.

Democratic incumbent Rick Lopes was reelected to a second term after defeating Republican candidate Tremell Collins.

Republican incumbent John Kissel was reelected to a 16th term after defeating Democratic candidate Cynthia Mangini.

Democratic incumbent Matt Lesser was reelected to a third term after defeating Republican candidate Lisa Marotta.

Democratic incumbent Gary Winfield was reelected to a fourth term after defeating Republican candidate John Carlson.

Democratic incumbent and Senate President Pro Tempore Martin Looney was reelected to a 16th term after defeating Republican candidate Steve Orosco.

Democratic incumbent James Maroney was reelected to a third term after defeating Republican candidate Kim-Marie Mullin.

Republican incumbent Heather Somers was reelected to a fourth term after defeating Democratic candidate Farouk Rajab.

Democratic incumbent Cathy Osten was reelected to a sixth term after defeating Republican candidate Pietro Camardello.

Republican incumbent and Senate Minority Leader Kevin C. Kelly was reelected to a seventh term after defeating Democratic candidate Christopher Green.

Democratic incumbent Marilyn Moore was reelected to a fifth term after defeating Libertarian candidate Wilfredo Martinez.

He faced felony charges for alleged campaign finance violations committed during his first run in 2018, and was defeated in the primary.

Democratic incumbent Patricia Billie Miller was reelected to a second term after defeating Republican candidate Michael Battinelli.

Republican incumbent Tony Hwang was reelected to a fifth term after defeating Democratic candidate Timothy Gavin.

Republican incumbent Henri Martin was reelected to a fifth term after defeating Democratic candidate Greg Hahn.

Republican incumbent Eric Berthel was reelected to a fourth term after defeating Democratic candidate Jeff Desmarais.

Democratic incumbent Norm Needleman was reelected to a third term after defeating Republican candidate Brandon Goff.

Republican incumbent Paul Cicarella was reelected to a second term after defeating Green Party candidate David Bedell.

Republican incumbent Ryan Fazio was reelected to a second term after defeating Democratic candidate Trevor Crow, a therapist.

Fazio had represented the 36th District since 2021 when he won a special election to finish the term of Democrat Alex Kasser who resigned after her divorce litigation with her former husband Seth Bergstein impacted her ability to do the job.