[2] The tournament returned for the first time in four years after the last scheduled edition in 2020 was cancelled due to the effects of the COVID-19 pandemic in South America.

[3][4] Brazil were the two-time defending champions, but lost in the final to hosts Paraguay who won their first ever title,[4][5][6] and claimed the first CONMEBOL competition victory by any senior Paraguayan team since the 1979 Copa América.

One venue was used in the city of Luque, part of the Greater Asunción area, on the grounds of the Paraguayan Olympic Committee headquarters.

In consideration of the ongoing COVID-19 pandemic, any of these registered players who become afflicted by the disease could be freely replaced before the tournament began (Regulations Article 33).

[9] If two or more teams are equal on points, their rankings are determined as follows (Regulations Article 20):[9] Matches are listed as local time in Luque, PYT (UTC−4).