Led by Rick Chamberlin in his 14th and final season as head coach, the Flyers compiled an overall record of 8–3 with a mark of 6–2 in conference play, tying for second place in the PFL with Davidson.

The St. Thomas Tommies won the conference title, but were ineligible for the postseason because of the program's five-year transition from NCAA Division III competition to the NCAA Division I Football Championship Subdivision (FCS).

Davidson, by virtue of a head-to-head win over Dayton in the final week of the regular season, earned the PFL's automatic bid to the NCAA Division I Football Championship playoffs.

The Pioneer League released their preseason coaches' poll on August 1, 2022.

The Flyers were picked to finish in fourth place.