In February 2021, Ohio Treasurer Robert Sprague named the school one of three Ohio Compass Award honorees[2] of the month for its financial education curriculum and partnership with Sinclair Community College with its College Credit Plus program.

Wayne High School competes interscholastically in boys and girls sports as a member of the Greater Western Ohio Conference (GWOC).

The Warriors primary league rival is Centerville High School.

[3] In its 65+ year history, Wayne's varsity football team has won several conference championships and has played in the OHSAA playoff tournament 23 times.

[5] The football and soccer teams play home games at Good Samaritan Athletic Field at Heidkamp Stadium.