The 2022 Dixie Vodka 400 was a NASCAR Cup Series race held on October 23, 2022, at Homestead-Miami Speedway in Homestead, Florida.

John Hunter Nemechek replaced Bubba Wallace for this race, as Wallace was parked by NASCAR for intentional retaliatory collision against Kyle Larson the previous race that collected playoff contender Christopher Bell.

[8] John Hunter Nemechek was the fastest in the practice session with a time of 32.299 seconds and a speed of 167.188 mph (269.063 km/h).

Rick Allen, Jeff Burton, Steve Letarte and Dale Earnhardt Jr. called the race from the broadcast booth.

Steve Post, Georgia Henneberry, Brienne Pedigo, and Jason Toy covered the action of the race for MRN on pit road.