The top eight finishers in the regular season qualified for the playoffs, which consists of four series of two teams each, played in a best-of-five format.
The winners of each of the playoffs series advanced to the Final Four, which determined the EuroLeague champion for the 2021–22 season.
When more than two teams are tied, the ranking will be established taking into account the victories obtained in the games played only among them.
[1] The first playoff series was determined on 6 April 2022, when Bayern Munich lost a match in Istanbul to the defending league champions Anadolu Efes.
[2] The result between Bayern and Anadolu Efes also secured the seventh-place spot for AS Monaco, who will make their first EuroLeague Playoffs appearance.