The Women's 100 metre butterfly competition of the 2022 FINA World Swimming Championships (25 m) was held on 17 and 18 December 2022.

[1] Prior to the competition, the existing world and championship records were as follows.

The following records was established during the competition: The heats were started on 17 December at 12:05.

[2] The swim-off was held on 17 December at 13:33.

[3] The semifinals were started on 17 December at 21:07.